Robust state estimation of feeding–blending systems in continuous pharmaceutical manufacturing

Control Systems Engineering in Continuous Pharmaceutical Manufacturing May 20-21, 2014 Continuous Manufacturing Symposium.

This white paper provides a perspective of the challenges, research needs, and future directions for control systems engineering in continuous pharmaceutical processing. The main motivation for writing this paper is to facilitate the development and deployment of control systems technologies so as to ensure quality of the drug product. Although the main focus is on small-molecule pharmaceutical...

Robust state estimation in power systems using pre-filtering measurement data

State estimation is the foundation of any control and decision making in power networks. The first requirement for a secure network is a precise and safe state estimator in order to make decisions based on accurate knowledge of the network status. This paper introduces a new estimator which is able to detect bad data with few calculations without need for repetitions and estimation residual cal...

robust state estimation in power systems using pre-filtering measurement data

state estimation is the foundation of any control and decision making in power networks. the first requirement for a secure network is a precise and safe state estimator in order to make decisions based on accurate knowledge of the network status. this paper introduces a new estimator which is able to detect bad data with few calculations without need for repetitions and estimation residual cal...

Flexible Multipurpose Continuous Processing of Pharmaceutical Tablet Manufacturing Process

Heterogeneous Nucleation of Active Pharmaceutical Ingredients on Polymers: Applications in Continuous Pharmaceutical Manufacturing

In this thesis work, we aimed to explore crystallization processes for small molecule API compounds based on engineered polymer surfaces that could be used in continuous manufacturing. First, we identified a library of polymers that can be used and selected PVA as the model polymer based on its solution and film properties. We also illustrated a rational approach for designing and fabricating P...